Papachristou D, Fortner J G
Ann Surg. 1977 Jan;185(1):13-6. doi: 10.1097/00000658-197701000-00002.
Wide excision of primary malignant melanoma en bloc with regional lymphadenectomy decreases the incidence of regional recurrence as compared with a discontinuous dissection. The more extensive soft tissue defect of the incontinuity procedure is of concern since major lymphatics are often ablated from the ankle region up to the aortic bifurcation. This problem was studied in 81 currently living patients, all of whom had been operated upon for primary melanoma located below the distal thigh. Measurable lymphedema was found in 64% who had had the incontinuity procedure and 69% in the discontinuity group. The incidence of advanced lymphedema (greater than two inches) was 23% and 36%, respectively. All patients with advanced edema had been operated upon more than 3 years ago. Eighty per cent of patients operated upon more than 5 years ago had lymphedema. Wound complications had occurred in 41% of the patients in the incontinuity group and 42% in the discontinuity group, but this did not affect the incidence of edema. The clinical findings are readily explainable on the basis of lymphangiographic data.
与不连续切除相比,原发性恶性黑色素瘤整块广泛切除联合区域淋巴结清扫可降低区域复发率。不连续手术造成的更广泛软组织缺损令人担忧,因为主要淋巴管常从踝区直至主动脉分叉处被切除。对81名在世患者进行了此项研究,他们均因位于大腿远端以下的原发性黑色素瘤接受了手术。在接受不连续手术的患者中,64%出现了可测量的淋巴水肿,连续手术组为69%。严重淋巴水肿(超过两英寸)的发生率分别为23%和36%。所有出现严重水肿的患者均在3年多前接受了手术。5年多前接受手术的患者中,80%出现了淋巴水肿。不连续手术组41%的患者和连续手术组42%的患者出现了伤口并发症,但这并未影响水肿的发生率。根据淋巴管造影数据,这些临床发现很容易得到解释。