Modena L
Divisione di Medicina Interna, Ospedale Civile, Soave Verona.
Minerva Med. 1993 May;84(5):263-8.
Forty outpatients of both sexes suffering from irritable colon syndrome were treated for four weeks with rociverine, an antispastic agent with anti-muscarinic and direct miolytic activities, at a dose of 20 mg x 3. The aim of the study was to assess the efficacy and tolerability of this dose since the drug is normally administered at a dose of 30-40 mg a day. The efficacy of treatment was assessed on the basis of the evolution of clinical symptoms, whereas its tolerability was evaluated in both clinical and biohumoral terms. The results of the study showed that a dose of 60 mg/die of causes a marked and significant reduction of the typical symptoms of irritable colon, in particular abdominal pain, with no variation in analytical findings and a small number of clinically unimportant side effects.
40名患有肠易激综合征的男女门诊患者接受了为期四周的罗西维林治疗，罗西维林是一种具有抗毒蕈碱和直接解痉活性的抗痉挛药物，剂量为20毫克×3次。该研究的目的是评估此剂量的疗效和耐受性，因为该药物通常的给药剂量为每天30 - 40毫克。根据临床症状的变化评估治疗效果，而从临床和生物体液方面评估其耐受性。研究结果表明，每天60毫克的剂量可显著减轻肠易激综合征的典型症状，尤其是腹痛，且分析结果无变化，仅有少量临床上不重要的副作用。
