Glynn C J, Stannard Cathy, Collins P A, Casale Roberto
Oxford Regional Pain Relief Unit, Churchill Hospital, Headington, and Nuffield Department of Anaesthetics, Radcliffe Infirmary, OxfordUK Service of Clinical Neurophysiology, Rehabilitation Center of Montescano, MontescanoItaly.
Pain. 1993 Apr;53(1):39-42. doi: 10.1016/0304-3959(93)90053-R.
The aim of the present study was to investigate the role of the peripheral cholinergic system in patients with sympathetically maintained pain (SMP). Thirty-three patients with SMP were given Bier's block with 0.6 mg of atropine in 10 ml of saline or 10 ml of saline in a randomised double-blind manner. Pain intensity, pain relief and mood were assessed before and after each block using the visual analogue scale (VAS). In addition pain intensity was assessed at the same time using a categorical scale (CS). There was at least 1 week between each injection, and during this week the patients reported their pain intensity daily, using the CS. Three patients failed to complete both wings of the study and thus the results of the remaining 30 patients were analysed using the Mann-Whitney U test and the Wilcoxon signed-rank test. No significant difference was found between atropine and saline on any parameter.
本研究的目的是探讨外周胆碱能系统在交感神经维持性疼痛（SMP）患者中的作用。33例SMP患者以随机双盲方式接受了在10ml生理盐水中加入0.6mg阿托品的比尔氏阻滞或单纯10ml生理盐水。每次阻滞前后使用视觉模拟量表（VAS）评估疼痛强度、疼痛缓解情况和情绪。此外，同时使用分类量表（CS）评估疼痛强度。每次注射之间至少间隔1周，在此期间患者每天使用CS报告其疼痛强度。3例患者未完成研究的两个阶段，因此使用曼-惠特尼U检验和威尔科克森符号秩检验对其余30例患者的结果进行了分析。在任何参数上，阿托品和生理盐水之间均未发现显著差异。
