Nishihara K, Tsuneyoshi M, Niiyama H, Ichimiya H
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Pathology. 1993 Jan;25(1):90-4. doi: 10.3109/00313029309068910.
A composite glandular-endocrine cell carcinoma of the extrahepatic bile duct in a 64 yr old Japanese man is reported. A nodular polyp measuring 1.9 x 1.1 cm was located in the confluence of the extrahepatic bile duct. Histologically, the tumor was composed of well differentiated tubular adenocarcinoma and small cell neuroendocrine carcinoma with a transition between the 2 components. The 2 areas of the tumor immunohistochemically revealed a clear-cut difference in functional differentiation. Tumor cells in the glandular component were immunoreactive to both carcinoembryonic antigen (CEA) and CAM 5.2, while those in the small cell area were immunoreactive to neuroendocrine markers such as neuron specific enolase (NSE), chromogranin A and serotonin. These results suggest that the tumor arose from a multipotential stem cell capable of differentiation in 2 directions.
报道了一名64岁日本男性肝外胆管复合性腺内分泌细胞癌。一个大小为1.9×1.1 cm的结节状息肉位于肝外胆管汇合处。组织学上，肿瘤由高分化管状腺癌和小细胞神经内分泌癌组成，两种成分之间有过渡。肿瘤的两个区域免疫组化显示功能分化有明显差异。腺性成分中的肿瘤细胞对癌胚抗原（CEA）和CAM 5.2均有免疫反应，而小细胞区域的肿瘤细胞对神经内分泌标志物如神经元特异性烯醇化酶（NSE）、嗜铬粒蛋白A和5-羟色胺有免疫反应。这些结果表明，该肿瘤起源于能够双向分化的多能干细胞。
