Thawley S E, Black M J, Dudek S E, Spector G J
Arch Otolaryngol. 1977 Jan;103(1):55-7. doi: 10.1001/archotol.1977.00780180093014.
A 24-year-old woman had epidermolysis bullosa simplex involving the external ear canal with resultant stricture that led to conductive hearing loss and repeated episodes of external otitis. Treatment consisted of scar excision, bony canal enlargement, and split-thickness skin grafting. A four-year follow-up has demonstrated no recurrence of disease. Mechanobullous diseases are characterized by blistering of the skin and mucous membrane following frictional trauma. In addition, the external ear may be deformed. Intraoral scarring may result in limitation of the mouth's opening. Dysphagia may occur secondarily to esophageal scarring. Endotracheal tubation may result in postoperative blisters necessitating tracheostomy. Even surgical scrubbing and use of skin tape may lead to blister formation. The otolaryngologist should be aware of the numerous problems these patients present.
一名24岁女性患有单纯性大疱性表皮松解症，累及外耳道，导致狭窄，进而引起传导性听力损失和反复的外耳道炎发作。治疗包括瘢痕切除、骨性耳道扩大和中厚皮片移植。四年的随访显示疾病未复发。机械性大疱性疾病的特征是摩擦创伤后皮肤和黏膜出现水疱。此外，外耳可能会变形。口腔内瘢痕形成可能导致张口受限。吞咽困难可能继发于食管瘢痕形成。气管内插管可能导致术后水疱形成，需要进行气管切开术。甚至手术刷洗和使用皮肤胶带也可能导致水疱形成。耳鼻喉科医生应了解这些患者出现的众多问题。
