Sellers D R, Kirkland J S, Kennealy J A, Oloff C M, Vittorio N
Aviat Space Environ Med. 1977 Jan;48(1):1-4.
Circulating levels of lactate dehydrogenase, glutamate-oxaloacetate, glutamate-pyruvate transaminase, and creatine phosphokinase, as well as its isoenzymes, were measured to investigate the possibility of myocardial damage during acceleration to high +Gz. Serum samples were analyzed in 12 human volunteers before, 6 h after, and 24 h after several bouts of accleration to 6, 8, 9, and 10 G. No substantial elevations of enzyme activities were observed. However, multivariate analysis of variance and multiple comparisons of the data indicated a small but statistically significant (p less than 0.01) increase in creatine phosphokinase. The results were consistent with enhanced skeletal muscle cell permeability consequent to muscular exercise.
检测乳酸脱氢酶、谷草转氨酶、谷丙转氨酶和肌酸磷酸激酶及其同工酶的循环水平，以研究在加速至高 +Gz 过程中心肌损伤的可能性。在 12 名人类志愿者进行几次加速至 6、8、9 和 10 G 的试验之前、之后 6 小时和 24 小时采集血清样本进行分析。未观察到酶活性有显著升高。然而，方差的多变量分析和数据的多重比较表明肌酸磷酸激酶有小幅但具有统计学意义（p 小于 0.01）的升高。结果与肌肉运动导致骨骼肌细胞通透性增强一致。
