Shushakova N D, Rychkova M P, Efimova M G
Zh Evol Biokhim Fiziol. 1993 Mar-Apr;29(2):146-53.
Maximal activity of NADP.H-cytochrome c reductase was found in the liver, the lowest one--in the retina. On the contrary, the highest activity of aldose reductase was observed in the retina, the lowest one--in the liver. The activity of NADP.H-cytochrome c reductase in the retina of rats with hereditary degeneration of the retina increased to the 60th day of postnatal life by 33%, the increase reaching 273% to the 90th day. In the brain cortex, the increase in the activity to the 45-60th days amounted to 22-34%, whereas at the age of 90 days the difference between healthy and patient rats, as well as the difference between males and females became less significant. The activity of aldose reductase in the cortex and retina in patient rats at the 20th day was 35% lower than in healthy animals. In the liver of patient rats, to the age of 45 days, the activity of aldose reductase decreased by 38%. At other periods, no significant differences were observed between healthy and patient animals with respect to the activity of this enzyme.
NADP.H-细胞色素c还原酶的最大活性在肝脏中被发现，最低活性在视网膜中。相反，醛糖还原酶的最高活性在视网膜中观察到，最低活性在肝脏中。患有遗传性视网膜变性的大鼠视网膜中，NADP.H-细胞色素c还原酶的活性在出生后第60天增加了33%，到第90天增加到273%。在大脑皮层中，到第45 - 60天活性增加了22 - 34%，而在90天龄时，健康大鼠和患病大鼠之间的差异以及雄性和雌性之间的差异变得不那么显著。患病大鼠在第20天时，皮层和视网膜中醛糖还原酶的活性比健康动物低35%。在患病大鼠的肝脏中，到45天龄时，醛糖还原酶的活性下降了38%。在其他时期，健康动物和患病动物在这种酶的活性方面没有观察到显著差异。
