Lukaszewska I
Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
Acta Neurobiol Exp (Wars). 1993;53(1):243-50.
Memory of a novel object was examined in saline (Sal) and scopolamine (Scopo) treated rats (1.0 mg/kg). Scopo rats showed lower overall exploration time than Sal rats, resulting mainly from shorter durations per contact. In a second exposure to the same object, after 1 min or 20 min interval, both groups displayed marked decrease of exploration indicating between-session habituation. The shorter time spent by Scopo rats on investigation of an object during a single approach might be interpreted as a deficit in maintenance of attention. Nevertheless, Scopo rats were able to acquire sufficient information for the retention during 20 min interval, as indicated by habituation, which is an elementary index of memory.
在生理盐水（Sal）处理组和东莨菪碱（Scopo，1.0毫克/千克）处理组的大鼠中检测对新物体的记忆。Scopo处理组的大鼠总体探索时间比Sal处理组的大鼠短，这主要是由于每次接触的持续时间较短。在间隔1分钟或20分钟后再次接触同一物体时，两组的探索行为均显著减少，表明存在会话间习惯化。Scopo处理组的大鼠在单次接近过程中对物体进行调查的时间较短，这可能被解释为注意力维持方面的缺陷。然而，如习惯化所示，Scopo处理组的大鼠能够在20分钟的间隔内获取足够的信息以进行记忆保留，习惯化是记忆的一个基本指标。
