Sypecka J, Tosic M, Dolivo M, Domańska-Janik K, Matthieu J M
Department of Neurochemistry, Medical Research Center, Polish Academy of Sciences, Warsaw.
Acta Neurobiol Exp (Wars). 1993;53(1):281-4.
A term "paralytic tremor" (pt) is attributed to a neurological mutation of Chinchilla rabbits, affecting the development of the central nervous system (CNS). A quantification of myelin protein content indicates the strong CNS hypomyelination during the development (1-120 postnatal days). SDS-PAGE electrophoresis of total brain homogenates, followed by immunoblotting, shows a reduced concentration of major myelin-connected proteins. MBP deficiency corresponds approximately to the level of the hypomyelination, whereas PLP expression is drastically reduced.
