Steinkasserer A, Spurr N K, Sim R B
MRC Immunochemistry Unit, Dept. Biochemistry, Oxford, UK.
Agents Actions. 1993;38 Spec No:C59-60. doi: 10.1007/BF01991137.
Using a panel of somatic rodent-human cell hybrids, we show that the interleukin-1 receptor antagonist gene (IL-1RN) maps to the long arm of human chromosome 2. Linkage studies permitted the regional localization of this gene to band q14-21. This is the same region in which the IL-1 alpha and IL-1 beta genes are localized. Three yeast artificial chromosome (YAC) clones containing the IL-1RN gene were isolated, and these will be used for further characterization of this chromosome 2 region.
利用一组体细胞啮齿动物-人类细胞杂交体，我们发现白细胞介素-1受体拮抗剂基因（IL-1RN）定位于人类2号染色体长臂。连锁研究将该基因区域定位到q14-21带。这与IL-1α和IL-1β基因所在区域相同。分离出了三个包含IL-1RN基因的酵母人工染色体（YAC）克隆，这些克隆将用于对2号染色体该区域进行进一步的特征分析。
