Matsuo T
Department of Ophthalmology, Okayama University Medical School, Japan.
Nippon Ganka Gakkai Zasshi. 1993 Mar;97(3):289-96.
Prostaglandins can lower intraocular pressure when they are applied topically to the eye. This pressure-lowering effect is mediated by enhancement of uveoscleral outflow. Human ciliary muscle has binding sites (receptors) for prostaglandins and the EP2 receptor subtype is the predominant prostanoid receptor found in this muscle. Prostaglandins are thought to bind to these receptors located on the ciliary muscle, induce its relaxation, and promote the uveoscleral outflow. It is important to know the receptor type involved in the pressure reduction to design a new drug with less adverse effect and more potency.
局部应用于眼部时，前列腺素可降低眼压。这种降眼压作用是通过增强葡萄膜巩膜外流来介导的。人睫状肌有前列腺素的结合位点（受体），EP2受体亚型是该肌肉中发现的主要前列腺素受体。前列腺素被认为与睫状肌上的这些受体结合，诱导其松弛，并促进葡萄膜巩膜外流。了解参与降压的受体类型对于设计一种副作用更小、效力更强的新药很重要。
