Fingerote R J, Bain V G
Department of Medicine, University of Alberta, Edmonton, Canada.
Am J Gastroenterol. 1993 Jul;88(7):1000-10.
Fulminant hepatic failure (FHF) is defined as acute liver failure with hepatic encephalopathy in patients with no history or stigmata of chronic liver disease. Historically, its prognosis was extremely poor. However, the emergence of orthotopic liver transplantation as a viable form of therapy for liver failure and advances in intensive care medicine have improved patient survival dramatically. Treatment of this condition revolves around supportive medical care and timely referral for orthotopic liver transplantation as necessary. Treatment needs to be individualized for each patient, because prognosis varies, depending on the etiology of the condition. The clinical manifestations of FHF and the management of this condition are discussed. Future prospects for the management of FHF are also reviewed.
暴发性肝衰竭（FHF）的定义为既往无慢性肝病病史或体征的患者出现急性肝衰竭并伴有肝性脑病。从历史上看，其预后极差。然而，原位肝移植作为一种可行的肝衰竭治疗方式的出现以及重症医学的进展显著提高了患者的生存率。这种疾病的治疗主要围绕支持性医疗护理，并在必要时及时转诊进行原位肝移植。由于预后因病情病因不同而有所差异，因此治疗需要针对每个患者进行个体化。本文将讨论暴发性肝衰竭的临床表现及该疾病的管理。同时也会对暴发性肝衰竭管理的未来前景进行综述。
