Kobayashi H, Kitano K, Kishi E, Hara K, Ishida F, Saito H, Ota M, Furuta S
Second Department of Internal Medicine, Shinshu University School of Medicine, Nagano-Ken, Japan.
Am J Hematol. 1993 May;43(1):51-3. doi: 10.1002/ajh.2830430112.
We report a case of transfusion-associated graft-vs.-host disease (TA-GVHD) in a previously healthy, 58 year old Japanese man following an accidental injury. Despite intensive treatment, the patient died 22 days after the transfusion. Although many cases of fatal TA-GVHD have been reported in immunocompetent patients, only two are known to have developed this disorder unrelated to a surgical procedure. This is the first such case to be confirmed by HLA typing. Our report suggests that TA-GVHD can occur even in a healthy, immunocompetent recipient. Thus, it seems necessary to establish guidelines for the irradiation of cellular blood products before transfusion.
我们报告一例既往健康的58岁日本男性在意外受伤后发生的输血相关移植物抗宿主病（TA-GVHD）。尽管进行了强化治疗，患者在输血后22天死亡。虽然免疫功能正常的患者中已报告了许多致命性TA-GVHD病例，但已知仅有两例发生这种疾病与手术无关。这是首例经HLA分型确诊的此类病例。我们的报告提示，即使是健康、免疫功能正常的受血者也可能发生TA-GVHD。因此，似乎有必要制定输血前细胞血液制品辐照的指南。
