使用对数秩检验的临床试验所需患者数量表。
Tables of the number of patients required in clinical trials using the logrank test.
作者信息
Freedman L S
出版信息
Stat Med. 1982 Apr-Jun;1(2):121-9. doi: 10.1002/sim.4780010204.
PMID:7187087
Abstract
The logrank test is commonly used in the analysis of clinical trials in chronic diseases such as cancer. Existing tables for the number of patients required in such trials are based on the direct comparison of two proportions. This paper presents tables of numbers required in clinical trials using the logrank test and describes their use. The numbers required are considerably smaller than those in existing tables when the event-free proportions are small, but otherwise comparable.
摘要
对数秩检验常用于癌症等慢性疾病的临床试验分析中。此类试验所需患者数量的现有表格是基于两个比例的直接比较。本文给出了使用对数秩检验的临床试验所需数量的表格，并描述了其用法。当无事件比例较小时，所需数量比现有表格中的要小得多，但在其他情况下相当。
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