Eissele R, Neuhaus C, Trautmann M E, Funk A, Arnold R, Höfler H
Department of Pathology, Technical University, Munich, Germany.
Am J Pathol. 1993 Jul;143(1):283-91.
Amylin was isolated from human insulinomas, but there has been only preliminary data regarding whether this peptide can also be detected in other types of gastroenteropancreatic endocrine tumors. In the present study, immunohistochemical staining of 87 gastroenteropancreatic endocrine tumors demonstrated amylin immunoreactivity in 21.8% of the neoplasmas. Thirteen of 15 insulinomas, three of 21 gastrinomas, two of 29 nonfunctioning tumors, and one of 18 carcinoids were amylin-immunoreactive. Seventeen of the 19 amylin-immunoreactive tumors were primarily located in the pancreas, but two tumors were found in the intestine. Measurements of amylin messenger RNA expression in a few tumors revealed amylin synthesis in these tumors. Amylin immunoreactivity did not correlate with invasion and metastasis. However, the rate of curative resections was significantly higher in amylin-immunoreactive tumors. These results demonstrate for the first time that amylin immunoreactivity is not restricted to insulinomas and can also occur rarely in endocrine tumors of the intestine.
胰岛淀粉样多肽是从人胰岛素瘤中分离出来的，但关于这种肽是否也能在其他类型的胃肠胰内分泌肿瘤中检测到，目前只有初步数据。在本研究中，对87例胃肠胰内分泌肿瘤进行免疫组化染色，结果显示21.8%的肿瘤有胰岛淀粉样多肽免疫反应性。15例胰岛素瘤中有13例、21例胃泌素瘤中有3例、29例无功能性肿瘤中有2例以及18例类癌中有1例呈胰岛淀粉样多肽免疫反应阳性。19例有胰岛淀粉样多肽免疫反应性的肿瘤中，17例主要位于胰腺，但有2例肿瘤位于肠道。对少数肿瘤进行的胰岛淀粉样多肽信使核糖核酸表达检测显示这些肿瘤能合成胰岛淀粉样多肽。胰岛淀粉样多肽免疫反应性与侵袭和转移无关。然而，有胰岛淀粉样多肽免疫反应性的肿瘤根治性切除率明显更高。这些结果首次表明，胰岛淀粉样多肽免疫反应性并不局限于胰岛素瘤，也可罕见地出现在肠道内分泌肿瘤中。
