Houghton I T, Aun C S, Gin T, Lau J T, Oh T E
Department of Anaesthesia and Resuscitation, British Military Hospital, Hong Kong.
Anaesthesia. 1993 May;48(5):377-81. doi: 10.1111/j.1365-2044.1993.tb07007.x.
The incidence of myalgia after suxamethonium was determined in 200 fit military male dental patients of European, Chinese and Nepalese descent. Half received pancuronium 1 mg and the other half received saline pretreatment on a randomised double-blind basis. The percentage incidence of postsuxamethonium myalgia after saline or pancuronium was found to be: Europeans 26%, 13%; Chinese 13%, 7%; Nepalese 20%, 14%. Although pancuronium reduced the incidence of myalgia by about 50% overall, these values were not significantly different from each other. The recovery of spontaneous ventilation following suxamethonium was quicker in the Europeans than in the Asians (p < 0.05). Pancuronium pretreatment also delayed the recovery of spontaneous ventilation and recovery from neuromuscular block (p < 0.05) but this was independent of ethnicity. The Europeans recovered from anaesthesia more quickly than the Asians. It was concluded that ethnicity affected recovery from suxamethonium and from anaesthesia but was not of clinical relevance to the incidence of myalgia in male Asians and Europeans.
在200名欧洲、中国和尼泊尔裔的健康男性牙科患者中确定了琥珀酰胆碱后肌痛的发生率。一半患者接受1毫克泮库溴铵，另一半患者在随机双盲的基础上接受生理盐水预处理。生理盐水或泮库溴铵处理后琥珀酰胆碱后肌痛的发生率为：欧洲人分别为26%、13%；中国人分别为13%、7%；尼泊尔人分别为20%、14%。尽管泮库溴铵总体上使肌痛发生率降低了约50%，但这些数值彼此之间无显著差异。琥珀酰胆碱后欧洲人的自主通气恢复比亚洲人更快（p<0.05）。泮库溴铵预处理也延迟了自主通气的恢复和神经肌肉阻滞的恢复（p<0.05），但这与种族无关。欧洲人从麻醉中恢复得比亚洲人更快。得出的结论是，种族影响琥珀酰胆碱和麻醉后的恢复，但与亚洲和欧洲男性肌痛的发生率无临床相关性。
