Taheri S, Laster M J, Liu J, Eger E I, Halsey M J, Koblin D D
Department of Anesthesia, University of California, San Francisco 94143-0464.
Anesth Analg. 1993 Jul;77(1):7-11. doi: 10.1213/00000539-199307000-00003.
Because deviations from the Meyer-Overton rule may provide insights into the attributes of the anesthetic site of action, we characterized the solubility of the n-alkanes in various hydrophobic solvents (n-tetradecane, olive oil, n-octanol, and lecithin) as well as saline using variations on standard techniques. Increasing alkane chain length correlated with a decrease in solubility in saline and an increase in solubility in the hydrophobic solvents. The product of solubility in the hydrophobic solvents x the partial pressure (in atmospheres) required to produce anesthesia (i.e., the Meyer-Overton rule) did not produce a constant for any one of these solvents. The means and standard deviations for the products were: tetradecane, 65 +/- 103; olive oil, 33 +/- 63; n-octanol, 64 +/- 129; and lecithin, 16 +/- 26. Thus, our data suggest that the n-alkanes (especially those longer than n-heptane) do not follow the Meyer-Overton rule.
由于偏离迈耶-奥弗顿规则可能有助于深入了解麻醉作用位点的特性，我们采用标准技术的变体，对正构烷烃在各种疏水溶剂（正十四烷、橄榄油、正辛醇和卵磷脂）以及盐水中的溶解度进行了表征。烷烃链长度增加与在盐水中的溶解度降低以及在疏水溶剂中的溶解度增加相关。在这些溶剂中的任何一种中，疏水溶剂中的溶解度×产生麻醉所需的分压（以大气压计）（即迈耶-奥弗顿规则）的乘积都不是常数。这些乘积的均值和标准差分别为：正十四烷，65±103；橄榄油，33±63；正辛醇，64±129；卵磷脂，16±26。因此，我们的数据表明正构烷烃（尤其是那些比正庚烷长的）不遵循迈耶-奥弗顿规则。
