Coldham N G, Lai L C, Ghilchik M W, Walker M M, James V H, Reed M J
Department of Chemical Pathology, St. Mary's Hospital Medical School, London, U.K.
Anticancer Res. 1993 May-Jun;13(3):753-8.
We have assessed cell deletion in breast tumours removed surgically from postmenopausal women by measuring the distribution ratio of acid phosphatase activity between the bound (in the lysosome) and free (in the phagosome) states. In benign breast tumours the acid phosphatase distribution ratio was much higher than that found in untreated malignant breast tumours. The acid phosphatase distribution ratio was also measured before and after treatment in malignant breast tumours removed from eight patients treated with 4-hydroxyandrostenedione (4-OH A) and in six patients treated with medroxyprogesterone acetate (MPA). Elevated acid phosphatase distribution ratios in benign compared with malignant tumours, and in malignant tumours after treatment from four of eight patients treated with 4-OH A and from three of six patients treated with MPA, may suggest higher cell deletion in these patients.
我们通过测量酸性磷酸酶活性在结合状态（溶酶体中）和游离状态（吞噬体中）之间的分布比例，评估了从绝经后妇女手术切除的乳腺肿瘤中的细胞清除情况。在良性乳腺肿瘤中，酸性磷酸酶分布比例远高于未经治疗的恶性乳腺肿瘤。还测量了8例接受4-羟基雄烯二酮（4-OH A）治疗的患者以及6例接受醋酸甲羟孕酮（MPA）治疗的患者切除的恶性乳腺肿瘤治疗前后的酸性磷酸酶分布比例。与恶性肿瘤相比，良性肿瘤以及8例接受4-OH A治疗的患者中有4例、6例接受MPA治疗的患者中有3例治疗后恶性肿瘤的酸性磷酸酶分布比例升高，这可能表明这些患者的细胞清除率较高。
