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[原始细胞转化试验和嗜碱性粒细胞活化试验在视网膜血管炎中的诊断及预测重要性]

[Diagnostic and predictive importance of the blast transformation test and basophil activation test in retinal vasculitis].

作者信息

Sainte-Laudy J, Jobin D, Thillaye B, de Kozak Y, Faure J P, Le Hoang P

机构信息

Centre de Biologie, Lyon.

出版信息

Allerg Immunol (Paris). 1993 Mar;25(3):103-5.

PMID:8318138
Abstract

22 patients suffering from Birdshot retinochoroidopathy (10), idiopathic vasculitis (6) and Behcet disease (6) and treated by cyclosporine were tested at regular intervals during 11 to 38 months by the lymphocyte stimulation test (LST) and basophil degranulation test (HBDT) with S retinal antigen. These two tests were found frequently positive especially during acute inflammation for the LST. However HBDT was positive in all the patients before relapse of acute inflammation which is in favor of its predictive value and its involvement in the triggering of inflammation at the basophiles or at the local mast cell level.

摘要

22例患有鸟枪弹样视网膜脉络膜病变(10例)、特发性血管炎(6例)和白塞病(6例)且接受环孢素治疗的患者,在11至38个月期间定期接受淋巴细胞刺激试验(LST)和用视网膜抗原S进行的嗜碱性粒细胞脱颗粒试验(HBDT)检测。发现这两项试验经常呈阳性,尤其是在急性炎症期间LST呈阳性。然而,HBDT在所有患者急性炎症复发前均呈阳性,这有利于其预测价值以及其在嗜碱性粒细胞或局部肥大细胞水平引发炎症中的作用。

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