Wang H F, Popenoe E A
Biochim Biophys Acta. 1977 Jan 3;474(1):98-108. doi: 10.1016/0005-2787(77)90217-9.
Amounts of DNA polymerase alpha and beta were determined in extracts of chicken erythroid cells at various stages of development. Concentrations of both polymerase activities are high in erythroblasts which are still dividing, decline after the cells cease dividing and begin maturation, and become almost undetectable in the fully mature erythrocytes. While DNA polymerase alpha activity declines gradually, firmly bound DNA polymerase beta activity in the nuclei drops abruptly after the cells finish DNA synthesis and dividing. The amount of a low molecular weight DNA polymerase extractable with the cytoplasmic fraction, possibly DNA polymerase beta, is low in erythroblasts, increases in the more mature erythroid population and then declines to an undectable level in the fully mature erythrocytes.
测定了鸡红细胞在不同发育阶段提取物中DNA聚合酶α和β的含量。在仍在分裂的成红细胞中，两种聚合酶活性的浓度都很高，在细胞停止分裂并开始成熟后下降，而在完全成熟的红细胞中几乎检测不到。虽然DNA聚合酶α活性逐渐下降，但细胞核中紧密结合的DNA聚合酶β活性在细胞完成DNA合成和分裂后会突然下降。可从细胞质部分提取的低分子量DNA聚合酶（可能是DNA聚合酶β）的量在成红细胞中较低，在更成熟的红细胞群体中增加，然后在完全成熟的红细胞中下降到检测不到的水平。
