棘阿米巴角膜炎的发病机制：基于30例组织学分析的假说
Pathogenesis of acanthamoebic keratitis: hypothesis based on a histological analysis of 30 cases.
作者信息
Garner A
机构信息
Department of Pathology, University of London.
出版信息
Br J Ophthalmol. 1993 Jun;77(6):366-70. doi: 10.1136/bjo.77.6.366.
Abstract
The results of a histopathological study of 30 cases of Acanthamoeba keratitis are construed as indicating a four stage pathogenetic sequence: (1) initial infection, involving breaching of the surface epithelium; (2) keratocyte depletion by the invading trophozoites; (3) inflammatory response mediated by neutrophil polymorphonuclear leucocytes; (4) stromal necrosis attributable to leucocytic activity.
摘要
对30例棘阿米巴角膜炎进行组织病理学研究的结果被解释为表明了一个四阶段的发病机制序列：（1）初始感染，涉及表面上皮的破损；（2）入侵的滋养体导致角膜细胞耗竭；（3）由中性多形核白细胞介导的炎症反应；（4）由白细胞活性引起的基质坏死。
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