Hagberg B, Hagberg G, Olow I
Department of Paediatrics and Child Psychiatry, University of Göteborg, Sweden.
Acta Paediatr. 1993 Apr;82(4):387-93. doi: 10.1111/j.1651-2227.1993.tb12704.x.
The prevalence and origin of cerebral palsy in children born between 1983 and 1986 are reported. The crude live-birth prevalence was 2.49 per 1000; 1.56 for term births, 0.93 for preterm births. The increasing trend from 1970 persisted and was statistically significant for both groups. The most pronounced increase during 1983-1986 occurred in term cerebral palsy. The increasing use of neuroimaging techniques made the timing of damaging events more reliable. In term cerebral palsy, the origin was convincingly prenatal in 28% of cases and perinatal in 25%. The particular critical period for the brain damage underlying cerebral palsy was considered to be weeks 26-34 of gestation, i.e. when periventricular structures are extraordinarily vulnerable. In term infants, this occurs during late intrauterine life, while in the majority of preterms it occurs in early neonatal life. In total, two-thirds of cerebral palsy lesions might have been acquired during these decisive months of brain development.
报告了1983年至1986年出生儿童的脑瘫患病率及发病根源。粗活产患病率为每1000例中有2.49例；足月产为1.56例，早产为0.93例。1970年以来的上升趋势持续存在，两组均具有统计学意义。1983 - 1986年期间，足月脑瘫的增长最为显著。神经影像技术使用的增加使得损伤事件的时间判断更加可靠。在足月脑瘫中，28%的病例病因明确为产前，25%为围产期。脑瘫所涉及的脑损伤的特定关键时期被认为是妊娠第26 - 34周，即脑室周围结构格外脆弱的时期。对于足月婴儿，这发生在子宫内晚期，而对于大多数早产儿，这发生在新生儿早期。总体而言，三分之二的脑瘫损伤可能在大脑发育的这些关键月份中形成。
