Anticonvulsant activity of the gamma-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol .

作者信息

White H S, Hunt J, Wolf H H, Swinyard E A, Falch E, Krogsgaard-Larsen P, Schousboe A

机构信息

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84108.

出版信息

Eur J Pharmacol. 1993 May 12;236(1):147-9. doi: 10.1016/0014-2999(93)90238-d.

The N-4,4-diphenyl-3-butenyl derivative of the glial selective gamma-aminobutyric acid (GABA) uptake inhibitor 4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridin-3-ol (N-DPB-THPO), was tested for its ability to block sound-induced seizures in the audiogenic seizure-susceptible Frings mouse model of epilepsy. Following intracerebroventricular (i.c.v.) administration, N-DPB-THPO blocked tonic hindlimb extension in a dose- and time-dependent manner. At the doses tested no gross behavioral effects were noted.