Schott C A, Vetrovsky P, Stoclet J C
Université Louis Pasteur de Strasbourg, Laboratoire de Pharmacologie Cellulaire et Moléculaire-CNRS URA600, Illkirch, France.
Eur J Pharmacol. 1993 May 12;236(1):155-7. doi: 10.1016/0014-2999(93)90240-i.
The effects of L-arginine (10(-7) to 10(-2) M), L-lysine and L-ornithine were examined in endothelium-denuded rat aortic rings preincubated 4 h with lipopolysaccharide (10 micrograms/ml) and contracted with noradrenaline (3 microM). L-Lysine (10 mM) and L-ornithine (10-30 mM) slightly increased contraction and caused a rightward shift in concentration-relaxation curves in response to L-arginine. These cationic amino acids may compete with L-arginine for the lipopolysaccharide-induced NO-synthase or the amino acid transporter, or both.
研究了L-精氨酸（10⁻⁷至10⁻²M）、L-赖氨酸和L-鸟氨酸对用脂多糖（10微克/毫升）预孵育4小时并用去甲肾上腺素（3微摩尔）收缩的内皮剥脱大鼠主动脉环的影响。L-赖氨酸（10毫摩尔）和L-鸟氨酸（10 - 30毫摩尔）轻微增加收缩，并使对L-精氨酸的浓度-舒张曲线向右移位。这些阳离子氨基酸可能与L-精氨酸竞争脂多糖诱导的一氧化氮合酶或氨基酸转运体，或两者都竞争。
