Yayama K, Kawao M, Tujii H, Itoh N, Okamoto H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Eur J Pharmacol. 1993 May 19;236(2):337-8. doi: 10.1016/0014-2999(93)90609-l.
The appearance of nephrotic syndromes such as proteinuria, hypoalbuminemia, hypercholesterolemia and increase in blood nitrogen urea, induced in rats by injection of puromycin aminonucleoside was markedly inhibited by oral administration of Dup 753 (losartan), a novel angiotensin II receptor antagonist, at a dose of 1 or 2 mg/kg per day. The results suggest a possible involvement of the renin-angiotensin system in the development of puromycin aminonucleoside-induced nephrosis.
通过注射嘌呤霉素氨基核苷诱导大鼠出现蛋白尿、低白蛋白血症、高胆固醇血症和血尿素氮升高的肾病综合征表现，每天口服1或2毫克/千克剂量的新型血管紧张素II受体拮抗剂Dup 753（氯沙坦）可显著抑制这些表现。结果提示肾素-血管紧张素系统可能参与嘌呤霉素氨基核苷诱导的肾病的发生发展。
