Bovim G, Sjaastad O
Department of Neurology, Regionsykehuset i Trondheim, Trondheim University Hospital, Norway.
Headache. 1993 May;33(5):249-52. doi: 10.1111/j.1526-4610.1993.hed3305249.x.
The responses in cervicogenic headache to four different agents have been studied. Nitroglycerin was given sublingually to 27 patients. Eighteen patients got more than 20% increase of their headache. Of those with any headache increase at all, 12 got bilateral and 12 unilateral pain. The typical late cluster headache response to nitroglycerin was not seen in cervicogenic headache. The provocative effect of nitroglycerin seemed less marked in cervicogenic than in cluster headache. Oxygen inhalation, a frequently used treatment for cluster headache, was given to 14 patients with cervicogenic headache. In general, the effect seemed uncertain and probably clearly inferior to the effect in cluster headache. Ergotamine treatment (given to 13 patients) also seemed to be of little avail in cervicogenic headache. Morphine injections given to 11 cervicogenic headache patients resulted in "marked" improvement in 4, but complete pain freedom was only seen in 2 cases. In our opinion, the present results add further evidence to the view that different etiologic and pathogenetic factors underlie cervicogenic headache and cluster headache.
研究了四种不同药物对颈源性头痛的反应。对27例患者舌下含服硝酸甘油。18例患者头痛加剧超过20%。在所有头痛加剧的患者中，12例出现双侧疼痛，12例出现单侧疼痛。颈源性头痛未出现典型的丛集性头痛对硝酸甘油的反应。硝酸甘油在颈源性头痛中的激发作用似乎不如丛集性头痛明显。对14例颈源性头痛患者进行了吸氧治疗，这是丛集性头痛常用的治疗方法。总体而言，效果似乎不确定，可能明显不如对丛集性头痛的治疗效果。对13例患者进行了麦角胺治疗，在颈源性头痛中似乎也收效甚微。对11例颈源性头痛患者注射吗啡，4例“显著”改善，但仅2例完全止痛。我们认为，目前的结果进一步证明了颈源性头痛和丛集性头痛有不同的病因和发病机制。
