HLA-DQαβ异二聚体在胰岛素依赖型糖尿病和乳糜泻易感性中的不同剂量效应。

Different dose effect of HLA-DQ alpha beta heterodimers in insulin-dependent diabetes mellitus and celiac disease susceptibility.

作者信息

Petronzelli F, Multari G, Ferrante P, Bonamico M, Rabuffo G, Campea L, Mazzilli M C

机构信息

Department of Experimental Medicine, La Sapienza University, Rome, Italy.

出版信息

Hum Immunol. 1993 Mar;36(3):156-62. doi: 10.1016/0198-8859(93)90119-l.

DOI:10.1016/0198-8859(93)90119-l

PMID:8320134

Abstract

To compare the quantitative effect of the DQ alpha beta heterodimers DQ alpha 52 Arg+, beta 57 Asp- and DQ alpha 10501, beta 10201 on susceptibility to IDDM and CD, we characterized, at the genomic level, the DQ alpha 52 and DQ beta 57 residues of 50 IDDM Italian patients observed in Rome. The results were compared with those of a previous study concerning the oligotyping of DQ dimers in a group of CD children belonging to the same population. Our data confirm that both diseases are primarily associated with HLA-DQ alpha beta heterodimers, but the distributions of the respective susceptible DQA1 and DQB1 alleles in the two diseases were different. In fact, the highest risk of IDDM is for subjects alpha SS, beta SS that could express, by either cis- or trans-association, four susceptible heterodimers and decreases in proportion to the number of these; in regard to CD, the highest risk was found for individuals who carried only one predisposing heterodimer.

摘要

为比较DQαβ异二聚体DQα 52 Arg +、β 57 Asp -和DQα 10501、β 10201对胰岛素依赖型糖尿病（IDDM）和乳糜泻（CD）易感性的定量影响，我们在基因组水平上对在罗马观察到的50例意大利IDDM患者的DQα 52和DQβ 57残基进行了特征分析。将结果与先前一项关于同一人群中一组CD儿童DQ二聚体寡核苷酸分型的研究结果进行了比较。我们的数据证实，这两种疾病主要都与HLA - DQαβ异二聚体相关，但两种疾病中各自易感的DQA1和DQB1等位基因的分布有所不同。事实上，IDDM风险最高的是α SS、β SS个体，他们通过顺式或反式关联可表达四种易感异二聚体，且风险会随着这些异二聚体数量的减少而降低；对于CD，风险最高的是仅携带一种易感异二聚体的个体。