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[用于癌症的三联肝切除术]

[Triple hepatectomy for cancer].

作者信息

Elias D, Debaene B, Farhat F, Hoang J M, Lasser P

机构信息

Service de Chirurgie digestive carcinologique, Institut Gustave Roussy, Villejuif.

出版信息

J Chir (Paris). 1993 Mar;130(3):107-10.

PMID:8320294
Abstract

The resection of the metastases from digestive malignant lesions are always the most efficient treatment, if it is complete. However it must be performed without major operative risk. According to this point of view, it is logical to examine the feasibility of three successive hepatectomies for metastases. We report in this study our experience with five cases of triple hepatectomies performed for 4 colic cancers and 1 carcinoid cancer. Two major hepatectomies were performed during this third resection. The re-exposure of the liver was very difficult in 4 cases, and the texture of the liver parenchyma was flabby and abnormal in 5 cases (confirmed with the histologic study). The mean duration of the surgery was 307 minutes, the mean duration of the intermittent pedicle clamping was 59 minutes, and the mean blood loss was 1710 ml. No post-operative death occurred, and the morbidity was low. This 5 third hepatectomies have been compared, for the feasability, to the 41 second hepatectomies and to the 234 first hepatectomies which we have performed. In proportion as hepatectomies are carried out, the difficulties to expose the liver increase, the texture of the liver parenchyma gets spoiled and the duration of the operation increases. In conclusion, the third hepatectomies are technically difficult to perform, but they are feasable. However it is too early to be able to define their indications.

摘要

对于消化系恶性病变转移灶的切除,如果切除彻底,始终是最有效的治疗方法。然而,必须在无重大手术风险的情况下进行。从这一观点来看,探讨对转移灶进行连续三次肝切除术的可行性是合乎逻辑的。我们在本研究中报告了对4例结肠癌和1例类癌进行五次三联肝切除术的经验。在第三次切除术中进行了两次大肝切除术。4例患者肝脏再次显露非常困难,5例患者肝实质质地松弛且异常(经组织学研究证实)。手术平均时长为307分钟,间歇性肝蒂阻断平均时长为59分钟,平均失血量为1710毫升。无术后死亡发生,且发病率较低。已将这五次第三次肝切除术在可行性方面与我们所施行的41例第二次肝切除术和234例第一次肝切除术进行了比较。随着肝切除术次数的增加,肝脏显露难度增大,肝实质质地变差,手术时长增加。总之,第三次肝切除术在技术上实施困难,但可行。然而,现在就能够确定其适应证还为时过早。

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