Shibata H
Department of Veterinary Anatomy, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan.
J Comp Neurol. 1993 Apr 22;330(4):533-42. doi: 10.1002/cne.903300409.
The organization of projections from the anterior thalamic nuclei to the cingulate cortex was analyzed in the rat by the anterograde transport of Phaseolus vulgaris-leucoagglutinin. The rostral part of the anteromedial nucleus projects to layers I, V and VI of the anterior cingulate areas 1 and 2, layers I and III of the ventral orbital area, layers I, V and VI of area 29D of the retrosplenial area, and layers I and V of the caudal part of the retrosplenial granular and agranular areas. In contrast, the caudal part of the anteromedial nucleus projects to layer V of the frontal area 2, and layers I and V of the rostral part of the retrosplenial granular and agranular areas. The interanteromedial nucleus projects to layers I, III and V of the frontal area 2, layer V of the agranular insular area, and layers I, V and VI of area 29D. The anteroventral nucleus projects to layers I and IV of the retrosplenial granular area, whereas the anterodorsal nucleus projects to layers I, III and IV of the same area. Projections from the anteroventral and anterodorsal nuclei were, furthermore, organized such that their ventral parts project to the rostral part of the retrosplenial granular area, whereas their dorsal parts project to the more caudal part. The results suggest that the anterior thalamic nuclei project to more widespread areas and laminae of the cingulate cortex than was previously assumed. The projections are organized such that the anteromedial and interanteromedial nuclei project to layer I and the deep layers of the anterior cingulate and retrosplenial cortex, whereas the anteroventral and anterodorsal nuclei project to the superficial layers of the retrosplenial cortex. These thalamocortical projections may play important roles in behavioral learning such as discriminative avoidance behavior.
通过菜豆白细胞凝集素的顺行运输，在大鼠中分析了丘脑前核向扣带回皮质的投射组织。前内侧核的吻侧部分投射到前扣带区1和2的I、V和VI层，腹侧眶区的I和III层，压后皮质29D区的I、V和VI层，以及压后颗粒区和无颗粒区尾部的I和V层。相比之下，前内侧核的尾侧部分投射到额叶2区的V层，以及压后颗粒区和无颗粒区吻部的I和V层。前内侧间核投射到额叶2区的I、III和V层，无颗粒岛叶区的V层，以及29D区的I、V和VI层。前腹侧核投射到压后颗粒区的I和IV层，而前背侧核投射到同一区域的I、III和IV层。此外，前腹侧核和前背侧核的投射组织方式是，它们的腹侧部分投射到压后颗粒区的吻部，而背侧部分投射到更靠尾侧的部分。结果表明，丘脑前核投射到扣带回皮质的区域和层比以前认为的更广泛。这些投射的组织方式是，前内侧核和前内侧间核投射到前扣带回和压后皮质的I层和深层，而前腹侧核和前背侧核投射到压后皮质的浅层。这些丘脑皮质投射可能在行为学习如辨别性回避行为中发挥重要作用。
