Yamaguchi K, Yamaguchi K, Gaur V P, Turner J E
Department of Ophthalmology, Tohoku University School of Medicine, Sendai.
Jpn J Ophthalmol. 1993;37(1):16-27.
Retinal pigment epithelial cells (RPE) from young, healthy rats were transplanted into older rat eyes to test whether aging changes could be delayed or arrested in an appropriate model. The Fischer-344 rat, a model for studying age-related photo-receptor cell death, was used as the recipient, and the Long Evans rat (6- to 8-day-old) was used as the donor of young RPE. Morphometric analyses at 3 and 6 months after RPE transplantation demonstrated a significant delay in age-related cell death in the outer and inner nuclear layers and in the outer and inner plexiform layers, as compared with the findings in controls. These results indicated the beneficial effects of RPE transplantation into the aging eye.
将年轻健康大鼠的视网膜色素上皮细胞（RPE）移植到老年大鼠眼中，以测试在合适的模型中衰老变化是否可以延迟或停止。将用于研究年龄相关性光感受器细胞死亡的Fischer-344大鼠作为受体，将长Evans大鼠（6至8日龄）作为年轻RPE的供体。RPE移植后3个月和6个月的形态计量学分析表明，与对照组相比，外核层和内核层以及外网状层和内网状层中与年龄相关的细胞死亡明显延迟。这些结果表明RPE移植到衰老眼中具有有益作用。
