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Absence of effects of class III antiarrhythmic agents on cloned cardiac K channels.

作者信息

Yamagishi T, Ishii K, Taira N

机构信息

Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Jpn J Pharmacol. 1993 Apr;61(4):371-3. doi: 10.1254/jjp.61.371.

DOI:10.1254/jjp.61.371
PMID:8320883
Abstract

We investigated the effects of class III antiarrhythmic agents, d-sotalol, E-4031 and MS-551, on the currents of two cloned K channels, Kv1.2 (IKv1.2) and Kv1.4(IKv1.4), by using the Xenopus oocyte expression system. Both IKv1.2 and IKv1.4 were sensitive to 4-aminopyridine and quinidine, but insensitive to tetraethylammonium, d-sotalol, E-4031 and MS-551. The results suggest that some types of structural proteins may be necessary for class III agents to inhibit the cardiac cloned K channels.

摘要

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