Greenwood J D
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada.
Lab Anim Sci. 1993 Apr;43(2):151-5.
The hu-PBL-scid has been constructed by intraperitoneal inoculation of lymphocytes from human peripheral blood into immunodeficient scid mice. Such scid mouse-human chimeras have proven useful as in vivo animal models for studies on human lymphocyte development and differentiation from pluripotent stem cells. Further, the hu-PBL-scid mouse provides a readily accessible model for the examination of immune cell function and involvement in autoimmune and infectious disease processes. In response to the growing need for model systems to examine the immune system and disease pathogenesis in agriculturally important animals, PBL engraftment of scid mice has expanded to include the bovine and equine species. This review discusses the properties and potential uses of the xenogeneic PBL-reconstituted scid mouse.
通过将人外周血淋巴细胞腹腔内接种到免疫缺陷的scid小鼠中构建了人外周血淋巴细胞-严重联合免疫缺陷（hu-PBL-scid）小鼠。这种scid小鼠-人嵌合体已被证明是研究人淋巴细胞从多能干细胞发育和分化的有用体内动物模型。此外，hu-PBL-scid小鼠为检查免疫细胞功能以及免疫细胞在自身免疫和传染病过程中的作用提供了一个易于使用的模型。为了满足对用于检查农业重要动物免疫系统和疾病发病机制的模型系统日益增长的需求，scid小鼠的外周血淋巴细胞移植已扩展到包括牛和马物种。本文综述了异种外周血淋巴细胞重建的scid小鼠的特性和潜在用途。
