假定的D-3多巴胺受体激动剂7-OH-DPAT相对于其他“D-2样”激动剂的行为效应。
Behavioural effects of the putative D-3 dopamine receptor agonist 7-OH-DPAT in relation to other "D-2-like" agonists.
作者信息
Daly S A, Waddington J L
机构信息
Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland.
出版信息
Neuropharmacology. 1993 May;32(5):509-10. doi: 10.1016/0028-3908(93)90177-5.
The putative D-3 dopamine receptor agonist 7-OH-DPAT (10 micrograms/kg, s.c.) reduced spontaneous activity in rats, without inducing yawning; higher doses (0.1-10.0 mg/kg, s.c.) stimulated non-stereotyped sniffing, locomotion and chewing, which were attenuated by the selective D-1 antagonist BW 737C (5.0 mg/kg, s.c.) without release of any atypical behaviours. Low doses of 7-OH-DPAT may act on inhibitory D-3 receptors, while higher doses may act at stimulatory D-3 or other "D-2-like" receptors that participate in cooperative but not oppositional interactions with D-1 receptors.
假定的D-3多巴胺受体激动剂7-羟基-DPAT（10微克/千克，皮下注射）可降低大鼠的自发活动，且不引起打哈欠；更高剂量（0.1-10.0毫克/千克，皮下注射）可刺激非刻板的嗅探、运动和咀嚼，选择性D-1拮抗剂BW 737C（5.0毫克/千克，皮下注射）可减弱这些反应，且不会引发任何非典型行为。低剂量的7-羟基-DPAT可能作用于抑制性D-3受体，而高剂量可能作用于刺激性D-3或其他“D-2样”受体，这些受体与D-1受体参与协同而非对立的相互作用。
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