Crampton G H
Wright State University, Dayton, Ohio.
ORL J Otorhinolaryngol Relat Spec. 1993 May-Jun;55(3):175-9. doi: 10.1159/000276416.
Research is urged for several motion sickness topics now receiving relatively little attention. The role of the area postrema, if any, is not completely resolved. The hypothesis that the cerebral spinal fluid might be a necessary neurochemical conduit should be confirmed or put to rest. It is surprising that the cerebellum, implicated more than 40 years ago, has not been reevaluated for its role in motion sickness in view of the explosion of new data on this structure. The sensory rearrangement theory, known by several names, needs direct experimental verification. One such experiment should determine if vestibular input is an essential element. Data interpretation problems related to rates of adaptation, often a consideration in sensory rearrangement experiments, are explored. The most exciting gains are to be achieved through neuropharmacologic approaches, particularly by exploiting the unique advantages offered by animal models.
目前有几个晕动病主题的研究受到的关注相对较少，因此有人呼吁开展相关研究。最后区（如果有作用的话）的作用尚未完全明确。脑脊液可能是一种必要的神经化学传导途径这一假说应得到证实或摒弃。令人惊讶的是，鉴于有关该结构的新数据激增，40多年前就被认为与晕动病有关的小脑，尚未针对其在晕动病中的作用进行重新评估。有几个名称的感觉重新排列理论需要直接的实验验证。这样的一个实验应该确定前庭输入是否是一个关键要素。探讨了与适应率相关的数据解释问题，这在感觉重新排列实验中常常是一个需要考虑的因素。最令人兴奋的成果将通过神经药理学方法来实现，特别是利用动物模型所提供的独特优势。
