Holman L E, Marshall K
SmithKline Beecham Pharmaceuticals, Pharmaceutical Sciences Department, King of Prussia, Pennsylvania 19406.
Pharm Res. 1993 Jun;10(6):816-22. doi: 10.1023/a:1018944724083.
For the calibration of a compaction simulator for punch displacement measurements, the displacement of the punch must be related to the voltage output of a linear variable displacement transducer (LVDT) which is attached to the punch via its movable core, with correction for any deformation of the machine parts which are inherently incorporated in the LVDT readings. Contrary to common assumptions the relationship between the displacement of the movable core and the voltage output of the LVDTs used is not linear. Similarly, the deformation of the machine parts did not follow Hooke's law of linear elasticity but exhibited characteristics of nonlinear elasticity. The data demonstrate the need for careful validation of the calibration of a compaction simulator when accurate punch displacements are required.
为了校准用于冲头位移测量的压实模拟器，冲头的位移必须与线性可变位移传感器（LVDT）的电压输出相关，该传感器通过其可移动铁芯连接到冲头，并对LVDT读数中固有包含的机器部件的任何变形进行校正。与常见假设相反，可移动铁芯的位移与所用LVDT的电压输出之间的关系不是线性的。同样，机器部件的变形并不遵循胡克线性弹性定律，而是表现出非线性弹性的特征。数据表明，当需要精确的冲头位移时，需要仔细验证压实模拟器的校准。
