Martonen T B, Katz I M
Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
Pharm Res. 1993 Jun;10(6):871-8. doi: 10.1023/a:1018913311788.
A mathematical model for inhaled aerosolized drugs is validated by comparisons of predicted particle deposition values with experimental data from adult subject inhalation exposure tests. The model is subsequently used to study the effects of ventilatory parameters on particle deposition patterns within the human lung. By altering breathing profiles, deposition values can be affected regarding quantity delivered and spatial location. Increased tidal volumes and breath-holding times increase deposition in the pulmonary region, while increased inspiratory flow rates increase deposition in the tracheobronchial region. Based upon fluid dynamics considerations (Reynolds numbers), an original method of partitioning the lung is also presented. The model has implications with regard to aerosol therapy, indicating that the efficacies of inhaled pharmacological drugs in the prophylaxis and treatment of airway diseases can be improved by regulating breathing profiles to deposit particles selectively at prescribed sites within the lung.
通过将预测的颗粒沉积值与成年受试者吸入暴露试验的实验数据进行比较，验证了吸入雾化药物的数学模型。随后，该模型用于研究通气参数对人肺内颗粒沉积模式的影响。通过改变呼吸模式，沉积值在输送量和空间位置方面会受到影响。潮气量和屏气时间增加会增加肺部区域的沉积，而吸气流量增加会增加气管支气管区域的沉积。基于流体动力学考虑（雷诺数），还提出了一种划分肺的原始方法。该模型对气溶胶疗法具有启示意义，表明通过调节呼吸模式以将颗粒选择性地沉积在肺内规定部位，可以提高吸入药理药物在预防和治疗气道疾病方面的疗效。
