葡萄糖影响新生仔猪缺氧缺血性脑损伤的严重程度。

Glucose affects the severity of hypoxic-ischemic brain injury in newborn pigs.

作者信息

LeBlanc M H, Huang M, Vig V, Patel D, Smith E E

机构信息

Department of Pediatrics, University of Mississippi Medical Center, Jackson 39216-4505.

出版信息

Stroke. 1993 Jul;24(7):1055-62. doi: 10.1161/01.str.24.7.1055.

DOI:10.1161/01.str.24.7.1055

PMID:8322380

Abstract

BACKGROUND AND PURPOSE

The administration of glucose has been shown to worsen brain injury in adult animals but has no effect on the severity of injury in newborn rats. We wished to see whether the results in newborn rats could be extended to another newborn animal.

METHODS

In 44 0- to 3-day-old piglets, hypoxic-ischemic central nervous system damage was induced by ligation of both carotid arteries and reduction of their blood pressure to two-thirds normal for one-half hour. In the last 15 minutes of this half hour, oxygen concentration was reduced to 6%. The piglets were randomized to receive either 2 mL/kg 50% dextrose in water followed by 2 mL/kg per hour for 2.5 hours beginning before ischemia or enough insulin to reduce their resting blood sugar to approximately 2 mmol/L.

RESULTS

Neurological exam scores in the glucose-treated piglets at 1 day after injury were significantly worse than those in the insulin-treated group. Pathological examination scores were poorer in the glucose-treated group (13.6 +/- 1.9 [mean +/- SEM]) than in the insulin-treated group (24.7 +/- 1.4, P < .01).

CONCLUSIONS

Increasing serum glucose during hypoxic-ischemic injury to the newborn piglet's brain worsens brain injury.

摘要

背景与目的

已证实给成年动物输注葡萄糖会加重脑损伤，但对新生大鼠的损伤严重程度并无影响。我们想了解新生大鼠的研究结果是否能推广至另一种新生动物。

方法

对44只0至3日龄仔猪，通过结扎双侧颈动脉并将血压降至正常的三分之二，持续半小时，诱导缺氧缺血性中枢神经系统损伤。在这半小时的最后15分钟，将氧浓度降至6%。仔猪被随机分为两组，一组在缺血前开始接受2 mL/kg 50%葡萄糖水溶液，随后每小时2 mL/kg，共2.5小时；另一组接受足够剂量的胰岛素以使静息血糖降至约2 mmol/L。