Freni S C, Keeman J N
Cancer. 1977 Jan;39(1):263-6. doi: 10.1002/1097-0142(197701)39:1<263::aid-cncr2820390140>3.0.co;2-b.
Excluding the rectum, smooth muscle cell tumors of the large bowel are extremely rare lesions. A unique case is reported of an infiltrating multinodular myomatous growth of semi-constrictive type affecting the ascending and transverse colon along its entire circumference and over a length of 35 cm. In the mesocolon near the colonic wall two tumor foci were present. Contrary to expectations from the growth behavior, histological examination revealed well differentiated smooth muscle cells with distinct myofilaments and absence of nuclear abnormalities and mitotic figures. No clinical evidence of malignancy was found and no recurrence was detected during a 39-month follow-up period which included a second-look operation. The contrasting fidings are discussed and it is concluded that the tumor should be considered a benign multicentric lesion, for which the term "leiomyomatosis of the colon" is suggested.
除直肠外，大肠平滑肌细胞瘤是极其罕见的病变。本文报告了一例独特病例，为半缩窄型浸润性多结节肌瘤样生长，累及升结肠和横结肠的整个周长，长度达35厘米。在靠近结肠壁的结肠系膜中有两个肿瘤病灶。与生长行为预期相反，组织学检查显示平滑肌细胞分化良好，有明显的肌丝，无核异常和有丝分裂象。未发现恶性肿瘤的临床证据，在包括二次探查手术在内的39个月随访期内未检测到复发。对这些对比结果进行了讨论，并得出结论，该肿瘤应被视为良性多中心病变，建议使用“结肠平滑肌瘤病”这一术语。
