Hancock B W, Bing R F, Dirmikis S M, Munro D S, Neal F E
Cancer. 1977 Jan;39(1):298-302. doi: 10.1002/1097-0142(197701)39:1<298::aid-cncr2820390146>3.0.co;2-c.
Ten patients with thyroid carcinoma and co-existing thyrotoxicosis have been studied. In six patients thyroid carcinoma was suspected before thyroidectomy. In three of the four patients in whom neoplasia was not suspected before operation, the lesion was a small papillary carcinoma. In only one of the eight patients in whom serum long acting thyroid stimulator (LATS) and long acting thyroid stimulator protector (LATSP) were assayed was detectable activity found, a low incidence. The possible role of hyperthyroidism in initiating thyroid malignancy is discussed.
对10例患有甲状腺癌并伴有甲状腺毒症的患者进行了研究。6例患者在甲状腺切除术前被怀疑患有甲状腺癌。在术前未怀疑有肿瘤形成的4例患者中，有3例病变为小乳头状癌。在8例检测血清长效甲状腺刺激素（LATS）和长效甲状腺刺激素保护物（LATSP）的患者中，仅1例检测到可检测的活性，发生率较低。文中讨论了甲状腺功能亢进在引发甲状腺恶性肿瘤中可能的作用。
