Niibori D, Fujisawa M, Matsuzaki M
Department of Urology, Fukagawa Municipal General Hospital.
Hinyokika Kiyo. 1993 May;39(5):459-61.
A case of renal failure in a patient with severe central nervous system symptoms during oral acyclovir medication is reported. A 68-year-old man maintained on hemodialysis was given oral acyclovir 4,000 mg daily in divided doses because of herpes zoster affecting the left C3/5 dermatomes. He had vomiting and confusion 36 hours after administration. He had no focal neurological signs. The symptoms resolved 4 days after cessation of acyclovir administration and blood purification every day. Because of its high therapeutic index the use of acyclovir is associated with few side effects. In patients with renal failure the half-life of acyclovir is prolonged, this report indicates the importance of adhering to the dosage reductions in patients with renal failure.
报告了1例口服阿昔洛韦期间出现严重中枢神经系统症状的肾衰竭患者。一名68岁维持性血液透析男性因带状疱疹累及左侧C3/5皮节，每日分剂量口服阿昔洛韦4000mg。给药36小时后出现呕吐和意识模糊。无局灶性神经体征。停用阿昔洛韦并每日进行血液净化4天后症状缓解。由于阿昔洛韦治疗指数高，其副作用较少。在肾衰竭患者中，阿昔洛韦半衰期延长，本报告指出了肾衰竭患者坚持减少剂量的重要性。
