Hayashi K, Chihara E, Sawa T, Tanaka Y
Department of Anaesthesiology, Kyoto Prefectural University of Medicine, Japan.
Anaesthesia. 1993 Jun;48(6):499-502. doi: 10.1111/j.1365-2044.1993.tb07070.x.
Hallervorden-Spatz disease is a rare autosomal recessive disorder in which dopaminergic deficiency in the substantia nigra and its nigrostriatal projection has been identified. It is characterised by a slow but progressive course culminating in death. This case report describes a 13-year-old male, with a clinical diagnosis of Hallervorden-Spatz disease, who developed recurrent episodes of an acute illness, the features of which closely resembled those of the neuroleptic malignant syndrome. However, in this patient there had been no exposure to neuroleptic medication. The clinical events in this case suggest that dopaminergic hypoactivity, which is characteristic of Hallervorden-Spatz disease, can trigger episodes of neuroleptic malignant syndrome.
哈勒沃登-施帕茨病是一种罕见的常染色体隐性疾病，已确定其黑质及其黑质纹状体投射存在多巴胺能缺乏。其特点是病程缓慢但呈进行性发展，最终导致死亡。本病例报告描述了一名13岁男性，临床诊断为哈勒沃登-施帕茨病，他出现了反复发作的急性疾病，其特征与抗精神病药物恶性综合征极为相似。然而，该患者未曾接触过抗精神病药物。本病例中的临床事件表明，哈勒沃登-施帕茨病所特有的多巴胺能活动减退可引发抗精神病药物恶性综合征发作。
