Kanno N, Abe T, Asai H, Yoshihara S, Ichimura T
First Department of Pediatrics, Dokkyo University School of Medicine.
Arerugi. 1993 May;42(5):643-8.
One hundred twenty five allergic patients ranging in age from 0 to 36 years old (mean age 9 years) were tested. Intradermal skin tests were performed on the volar surface of the forearm by injection of a five-fold dilution of histamine dihydrochloride (from 1 x 5(-5) mg/ml to 1 x 5(-2) mg/ml). The wheal diameters increased incrementally with histamine concentration. The whealing capacity of the skin to histamine was found to be significantly lower in patients 0 to 5 years of age. There was no difference in the mean wheal size between patients 6 to 10 and 11 to 15 years of age. The wheal size in patients 16 to 36 years of age were significantly larger than those in the other age groups. The flare diameters also increased incrementally with histamine concentration. The mean diameter of flares was significantly lower in patients 0 to 5 years of age. Concentrations between 1 x 5(-3) mg/ml and 1 x 5(-2) mg/ml of histamine dihydrochloride should be taken for a positive control in intradermal allergen skin tests.
对125名年龄在0至36岁（平均年龄9岁）的过敏患者进行了测试。在前臂掌侧进行皮内皮肤试验，注射五倍稀释的二盐酸组胺（浓度从1×5（-5）mg/ml到1×5（-2）mg/ml）。风团直径随组胺浓度递增。发现0至5岁患者皮肤对组胺的风团形成能力明显较低。6至10岁和11至15岁患者的平均风团大小没有差异。16至36岁患者的风团大小明显大于其他年龄组。红晕直径也随组胺浓度递增。0至5岁患者的平均红晕直径明显较低。在皮内过敏原皮肤试验中，应采用浓度在1×5（-3）mg/ml至1×5（-2）mg/ml之间的二盐酸组胺作为阳性对照。
