非颞叶癫痫患者在阿米妥试验中的记忆表现。
Memory performance during the Amytal test in patients with non-temporal lobe epilepsy.
作者信息
Dasheiff R M, Shelton J, Ryan C
机构信息
University of Pittsburgh Epilepsy Center, PA 15213.
出版信息
Arch Neurol. 1993 Jul;50(7):701-5. doi: 10.1001/archneur.1993.00540070021008.
PROBLEM
The amobarbital (Amytal) sodium test has been considered an indispensable tool in the presurgical examination of patients for epilepsy surgery. However, the accuracy of the Amytal test for predicting memory deficits, especially the amnestic syndrome, has been questioned.
METHOD
The Amytal test was administered bilaterally to three groups of patients with epilepsy: temporal lobe (n = 76), frontal lobe (n = 25), and primary generalized (n = 8). Each injected hemisphere for each patient was graded pass or fail for its ability to support memory.
RESULTS
The percentages of hemispheres that failed the Amytal test were 31% for the temporal lobe group, 32% for the frontal lobe group, and 56% for the primary generalized group.
CONCLUSIONS
The Amytal test may be a sensitive measure of memory dysfunction. However, the high percentage of failures remains at variance with the rare incidence of the amnestic syndrome, suggesting a low specificity for this test.
问题
异戊巴比妥钠试验一直被认为是癫痫手术患者术前检查中不可或缺的工具。然而，异戊巴比妥试验预测记忆缺陷，尤其是遗忘综合征的准确性受到了质疑。
方法
对三组癫痫患者双侧进行异戊巴比妥试验：颞叶癫痫组（n = 76）、额叶癫痫组（n = 25）和原发性全身性癫痫组（n = 8）。根据每个患者每个注射半球支持记忆的能力评定为通过或未通过。
结果
颞叶癫痫组异戊巴比妥试验未通过的半球比例为31%，额叶癫痫组为32%，原发性全身性癫痫组为56%。
结论
异戊巴比妥试验可能是记忆功能障碍的敏感指标。然而，较高的未通过比例与罕见的遗忘综合征发病率不一致，表明该试验的特异性较低。
Zotero 插件