Nielsen N H, Jensen H
Institute of Forensic Pathology, Copenhagen University, Denmark.
APMIS. 1993 Apr;101(4):290-4. doi: 10.1111/j.1699-0463.1993.tb00113.x.
During 1986-1991 diagnostic Pap smear examinations were performed in 10,998 Greenlandic women, corresponding to 60 per cent of all women over 14 years of age. Of these, more than half had at least two smears taken. Three-year screening coverage of women over 14 was 40 per cent. Screening intensity was highest in the 25-39 age group, where more than half the population was covered. Compared to the previous 10-year period, rates for all precursor lesions were considerably lower, most pronounced for carcinoma in situ. Such findings probably reflect previous screening experience rather than reduced background risk. However, cytological screening activity failed to reduce the incidence of invasive cancer-one of the world's highest. Most cancer patients had slipped through the system because of failure to be screened at all (57%) or failure of adequate follow-up (23%). Infrequent screening and possible false-negative results seem to account for most of the remaining cases. Cancer patients with a history of failed follow-up reflected an inadequate follow-up management over the last 15 years of women with abnormal smear results. The findings of this study were similar to results for 1976-1985. A nationwide, centrally organized mass screening programme is recommended.
1986年至1991年期间,对10998名格陵兰妇女进行了诊断性巴氏涂片检查,这相当于所有14岁以上妇女的60%。其中,超过一半的妇女至少接受了两次涂片检查。14岁以上妇女的三年筛查覆盖率为40%。筛查强度在25至39岁年龄组最高,该年龄组超过一半的人口接受了筛查。与前一个十年相比,所有癌前病变的发生率都大幅降低,原位癌最为明显。这些发现可能反映了以往的筛查经验,而非背景风险的降低。然而,细胞学筛查活动未能降低浸润性癌的发病率——其发病率在世界范围内处于最高水平之一。大多数癌症患者未被筛查(57%)或后续随访不足(23%),从而未能被纳入筛查系统。其余大多数病例似乎是由于筛查不频繁以及可能出现的假阴性结果。有随访失败病史的癌症患者反映出过去15年中对涂片结果异常的妇女随访管理不足。本研究的结果与1976年至1985年的结果相似。建议开展一项全国性的、集中组织的大规模筛查计划。