Manjula S, Aroor A R, Raja A, Rao S, Rao A
Department of Biochemistry, Kastruba Medical College, Manipal, Karnataka, India.
Acta Oncol. 1993;32(3):311-4. doi: 10.3109/02841869309093601.
Elevated urinary levels of modified nucleosides, especially pseudouridine (psi), have been observed in patients with a variety of malignant neoplasms. In this report, the urinary psi levels were estimated by high performance liquid chromatography in 93 patients with brain tumours and in 40 age and sex matched controls. The psi levels were found to be excreted in equal amounts in the control and the tumour groups. There was no significant difference in psi when patients with malignant diseases were compared with those with benign tumours. Following therapy, the psi levels remained unchanged when compared to the controls and their preoperative values. It is concluded that urinary psi concentration is not a useful marker for brain tumours.
在患有各种恶性肿瘤的患者中，已观察到尿液中修饰核苷水平升高，尤其是假尿苷（ψ）。在本报告中，通过高效液相色谱法对93例脑肿瘤患者和40例年龄及性别匹配的对照者的尿液ψ水平进行了评估。发现对照组和肿瘤组中ψ的排泄量相等。将恶性疾病患者与良性肿瘤患者相比，ψ水平没有显著差异。治疗后，与对照组及其术前值相比，ψ水平保持不变。结论是尿液ψ浓度不是脑肿瘤的有用标志物。
