Kleinschmidt S, Ziegenfuss T, Bauer M, Fuchs W
Klinik für Anästhesiologie und Intensivmedizin, Universitätskliniken des Saarlandes, Homburg, Saar.
Anasthesiol Intensivmed Notfallmed Schmerzther. 1993 Apr;28(2):81-5. doi: 10.1055/s-2007-998883.
In a clinical trial, the influence of repeated intermittent prone position on pulmonary gas exchange was investigated in 6 patients with severe ARDS. Despite various intra- and interindividual differences, oxygenation index (calculated by the paO2:FiO2 ratio) was improved significantly by change from supine to prone position in the first two days of treatment, whereas paCO2 remained unchanged. Later on, a significant improvement of oxygenation could not be verified. In patients with proven or presumed densities of dorsal lung regions, body position changes from supine to prone position in the early phase of treatment may improve arterial oxygenation and may be regarded as a therapeutic principle in conventional ARDS treatment.
在一项临床试验中，对6例重症急性呼吸窘迫综合征（ARDS）患者研究了反复间歇性俯卧位对肺气体交换的影响。尽管存在个体内和个体间的各种差异，但在治疗的前两天，从仰卧位改为俯卧位后，氧合指数（通过动脉血氧分压与吸入氧分数值之比计算）显著改善，而动脉血二氧化碳分压保持不变。后来，氧合的显著改善未能得到证实。对于已证实或推测存在肺背侧区域实变的患者，在治疗早期从仰卧位改为俯卧位可能会改善动脉氧合，可被视为传统ARDS治疗中的一项治疗原则。
