Waites G M
World Health Organisation, Special Programme of Research, Geneva, Switzerland.
Br Med Bull. 1993 Jan;49(1):210-21. doi: 10.1093/oxfordjournals.bmb.a072599.
The search for new, safe, effective and reversible contraceptive methods for men is being pursued by several agencies. The most likely developments before the year 2000 would appear to be: the introduction of more easily reversed procedures of vas occlusion; hormonal means of sperm suppression based on infrequent injections of androgens either alone or combined with other gonadotrophin-suppressing agents. Methods based on new drugs or vaccines are unlikely to be developed by the end of the decade. Research is needed to understand the basis of the differences in efficacy of contraceptive steroids in men of different ethnic origin. Equally there is a need to monitor the safety and acceptability of hormonal methods for men. New targets for drug intervention should be pursued through support of basic science, taking advantage of modern cellular and molecular biological techniques. Finally, the subject of Andrology needs to be strengthened throughout the world so that scientists in developing countries can participate fully in this work.
几个机构正在致力于寻找新的、安全、有效且可逆的男性避孕方法。2000年前最有可能取得的进展似乎是：采用更易于恢复的输精管阻塞手术；基于不频繁注射雄激素单独或与其他促性腺激素抑制药物联合使用的抑制精子生成的激素方法。基于新药或疫苗的方法在本十年末不太可能研发出来。需要开展研究以了解不同种族男性中避孕类固醇疗效差异的基础。同样，也有必要监测男性激素避孕方法的安全性和可接受性。应通过支持基础科学，利用现代细胞和分子生物学技术来探寻新的药物干预靶点。最后，全世界都需要加强男科学这一学科，以便发展中国家的科学家能够充分参与这项工作。
