模仿弧菌W-26768 O抗原多糖的结构研究。

Structural studies of the Vibrio mimicus W-26768 O-antigen polysaccharide.

作者信息

Kenne L, Lindberg B, Rahman M M, Mosihuzzaman M

机构信息

Department of Chemistry, Swedish University of Agricultural Sciences, Uppsala.

出版信息

Carbohydr Res. 1993 Apr 23;243(1):131-8. doi: 10.1016/0008-6215(93)84086-l.

DOI:10.1016/0008-6215(93)84086-l

PMID:8324759

Abstract

The structure of the Vibrio mimicus W-26768 O-antigen polysaccharide has been investigated by sugar and methylation analyses, Smith degradation, and NMR spectroscopy. It is proposed that it is composed of chains of beta-(1-->4)-linked 3,6-dideoxy-3-[(R)-3-hydroxybutyramido]-D-glucopyranosyl residues (D-Qui(p)3NR), approximately 60% of which are substituted in the 2-position with 2-acetamido-2-deoxy-alpha-D-galactopyranosyl groups. The polysaccharide does not seem to be composed of oligosaccharide repeating units but has a less regular structure, schematically indicated below. [formula: see text]

摘要

通过糖分析、甲基化分析、史密斯降解和核磁共振光谱对模仿弧菌W-26768 O抗原多糖的结构进行了研究。据推测，它由β-(1→4)连接的3,6-二脱氧-3-[(R)-3-羟基丁酰胺基]-D-吡喃葡萄糖残基（D-Qui(p)3NR）链组成，其中约60%在2位被2-乙酰氨基-2-脱氧-α-D-吡喃半乳糖基取代。该多糖似乎不是由寡糖重复单元组成，而是具有不太规则的结构，示意如下。[化学式：见原文]