严重联合免疫缺陷（SCID）小鼠作为自身免疫性疾病研究的模型。
The severe combined immunodeficient (SCID) mouse as a model for the study of autoimmune diseases.
作者信息
Vladutiu A O
机构信息
Department of Pathology, Buffalo School of Medicine and Biomedical Sciences, SUNY.
出版信息
Clin Exp Immunol. 1993 Jul;93(1):1-8. doi: 10.1111/j.1365-2249.1993.tb06488.x.
Abstract
There are no readily available in vivo models to study immune cells from humans with autoimmune diseases. SCID mice, which virtually lack both T and B lymphocytes and accept xenogeneic cells, have been used during the last 5 years to provide a milieu for lymphocytes isolated from individuals with various autoimmune diseases, or for lymphocytes from mice that have a systemic lupus erythematosus-like syndrome. Whilst human autoantibodies to organ antigens have been demonstrated in most SCID mice engrafted with human lymphocytes from the peripheral blood or the target organ, inflammation of the mouse target organ has not generally been observed. This review critically analyses experiments in this area reported so far. Some pitfalls of the SCID mouse model of human autoimmune diseases are mentioned, and future experiments to study mouse and human autoimmunity with this model are proposed.
摘要
目前尚无现成的体内模型可用于研究自身免疫性疾病患者的免疫细胞。严重联合免疫缺陷（SCID）小鼠几乎缺乏T淋巴细胞和B淋巴细胞，并能接受异种细胞，在过去5年中已被用于为从患有各种自身免疫性疾病的个体中分离出的淋巴细胞，或患有系统性红斑狼疮样综合征的小鼠的淋巴细胞提供一个环境。虽然在大多数移植了来自外周血或靶器官的人淋巴细胞的SCID小鼠中已证明存在针对器官抗原的人类自身抗体，但一般未观察到小鼠靶器官的炎症。本综述对迄今为止该领域报道的实验进行了批判性分析。文中提到了人类自身免疫性疾病SCID小鼠模型的一些缺陷，并提出了今后用该模型研究小鼠和人类自身免疫性的实验。
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