原发性醛固酮增多症可能并不罕见的证据：在抗高血压药物试验志愿者中的发病率为12%。

Evidence that primary aldosteronism may not be uncommon: 12% incidence among antihypertensive drug trial volunteers.

Gordon R D, Ziesak M D, Tunny T J, Stowasser M, Klemm S A

Endocrine-Hypertension Research Unit, Greenslopes Hospital, Brisbane, Queensland, Australia.

Clin Exp Pharmacol Physiol. 1993 May;20(5):296-8. doi: 10.1111/j.1440-1681.1993.tb01687.x.

Abstract

Six (12%) out of 52 respondents to newspaper advertisements for antihypertensive drug trials had elevated aldosterone to renin ratio, confirmed by repeated measurement. 2. Failure to suppress aldosterone with fludrocortisone acetate administration and oral salt loading confirmed the presence of primary aldosteronism in all six patients. 3. Two of the six patients have already had aldosterone-producing adenomas removed, one has commenced spironolactone, and one has an adrenal mass on computerized tomography but investigation is incomplete. 4. None of the six patients with primary aldosteronism had unprovoked hypokalaemia. 5. Plasma aldosterone levels did not distinguish those patients with subsequently proven primary aldosteronism from the others. Plasma renin activity (PRA) was a better discriminator, but not as good as the aldosterone to renin ratio. 6. The incidence of primary aldosteronism is probably much higher than the 1% currently quoted in texts, with earlier, normokalaemic forms accounting for the majority of cases.

摘要

在52名回应报纸上抗高血压药物试验广告的受访者中，有6人（12%）经反复测量证实醛固酮与肾素比值升高。2. 给予醋酸氟氢可的松并口服钠盐负荷后醛固酮未能被抑制，证实所有6例患者均存在原发性醛固酮增多症。3. 6例患者中有2例已切除产生醛固酮的腺瘤，1例已开始服用螺内酯，1例在计算机断层扫描中有肾上腺肿块，但检查尚未完成。4. 6例原发性醛固酮增多症患者均无自发性低钾血症。5. 血浆醛固酮水平无法区分随后被证实患有原发性醛固酮增多症的患者与其他患者。血浆肾素活性（PRA）是更好的鉴别指标，但不如醛固酮与肾素比值。6. 原发性醛固酮增多症的发病率可能远高于目前教科书中引用的1%，早期血钾正常的类型占大多数病例。